ANTAGONISTS TO NEUROMUSCULAR BLOCKING AGENTS: An Experimental Study

Antagonists to neuromuscular blocking agents. An experimental study.

T h : antagonism between tubocurarine and alcuronium chloride on the one hand and neostigmine, physostigmine, edrophonium and ambenonium on the other have been investigated. A quantitative measure of antagonism was obtained on the rat diaphragm preparation and it was found that in general the antagonists were more effective against alcuronium chloride than against tubocurarine. The antagonist d...

Neuromuscular Blocking Agents

• Neuromuscular blocking agents are used to improve conditions for tracheal intubation, to provide immobility during surgery, and to facilitate mechanical ventilation. • The main site of action of neuromuscular blocking agents (muscle relaxants) is on the nicotinic cholinergic receptor at the endplate of muscle. They also have effects at presynaptic receptors located on the nerve terminal. • Su...

Neuromuscular blocking agents: a review.

The author provides a review of the mechanism of neuromuscular transnission, as well as the Nechanisn of action and differences between curare and succinylcholine. Effects of these two relaxants on various organs and tissues are discussed, as are their onset of action, duration, elimination, and clinical uses. In order to understand how skeletal muscle re-laxants act, the mechanism of neuromusc...

Indications for Neuromuscular Blocking Agents

©International Anesthesia Research Society. Unauthorized Use Prohibited. Almost thirty years ago, residual neuromuscular blockade was documented in a surprisingly high proportion of patients (30%), despite an almost systematic use of anticholinesterase agents.1 Since then, even with the development of shorter-acting neuromuscular blockers, pharmacological reversal, and more widespread use of ne...

tracheal intubation without the use of neuromuscular blocking agents